Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3534593..3535211 Replicon chromosome
Accession NZ_CP122507
Organism Escherichia coli strain W444

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QC806_RS17435 Protein ID WP_001291435.1
Coordinates 3534993..3535211 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QC806_RS17430 Protein ID WP_000344800.1
Coordinates 3534593..3534967 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC806_RS17420 (3529682) 3529682..3530875 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QC806_RS17425 (3530898) 3530898..3534047 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QC806_RS17430 (3534593) 3534593..3534967 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QC806_RS17435 (3534993) 3534993..3535211 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QC806_RS17440 (3535383) 3535383..3535934 + 552 WP_000102564.1 maltose O-acetyltransferase -
QC806_RS17445 (3536050) 3536050..3536520 + 471 WP_000136192.1 YlaC family protein -
QC806_RS17450 (3536684) 3536684..3538234 + 1551 WP_063501968.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QC806_RS17455 (3538276) 3538276..3538629 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QC806_RS17465 (3539008) 3539008..3539319 + 312 WP_000409911.1 MGMT family protein -
QC806_RS17470 (3539350) 3539350..3539922 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277110 WP_001291435.1 NZ_CP122507:3534993-3535211 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277110 WP_000344800.1 NZ_CP122507:3534593-3534967 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References