Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 169326..169897 Replicon chromosome
Accession NC_017768
Organism Streptococcus mutans LJ23

Toxin (Protein)


Gene name mazF Uniprot ID A0A2J9QC66
Locus tag SMULJ23_RS00855 Protein ID WP_002265705.1
Coordinates 169565..169897 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2J9QC51
Locus tag SMULJ23_RS00850 Protein ID WP_002264866.1
Coordinates 169326..169571 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMULJ23_RS00815 164864..165532 + 669 WP_014677709.1 ArsR family transcriptional regulator -
SMULJ23_RS00820 165839..166151 + 313 Protein_143 thioredoxin -
SMULJ23_RS00825 166160..167080 + 921 WP_014677712.1 thioredoxin-disulfide reductase -
SMULJ23_RS00830 167080..167346 + 267 WP_148270968.1 hypothetical protein -
SMULJ23_RS00835 167347..167526 + 180 WP_014677714.1 type Z 30S ribosomal protein S14 -
SMULJ23_RS00840 167546..168196 + 651 WP_014677715.1 DsbA family oxidoreductase -
SMULJ23_RS00845 168356..168919 + 564 WP_014677717.1 DUF1211 domain-containing protein -
SMULJ23_RS00850 169326..169571 + 246 WP_002264866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SMULJ23_RS00855 169565..169897 + 333 WP_002265705.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SMULJ23_RS00860 170095..170886 - 792 WP_044560171.1 nucleotidyltransferase domain-containing protein -
SMULJ23_RS00865 171202..172962 + 1761 WP_002301189.1 PDZ domain-containing protein -
SMULJ23_RS00870 172964..173581 + 618 WP_002270664.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12664.56 Da        Isoelectric Point: 6.4634

>T27711 WP_002265705.1 NC_017768:169565-169897 [Streptococcus mutans LJ23]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T27711 NC_017768:169565-169897 [Streptococcus mutans LJ23]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCCAATATTGCTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTCCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9255.55 Da        Isoelectric Point: 4.3021

>AT27711 WP_002264866.1 NC_017768:169326-169571 [Streptococcus mutans LJ23]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp

>AT27711 NC_017768:169326-169571 [Streptococcus mutans LJ23]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATGTCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGTTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QC66

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9QC51

References