Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2294168..2294806 Replicon chromosome
Accession NZ_CP122507
Organism Escherichia coli strain W444

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QC806_RS11345 Protein ID WP_000813794.1
Coordinates 2294168..2294344 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QC806_RS11350 Protein ID WP_001270286.1
Coordinates 2294390..2294806 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC806_RS11325 (2289787) 2289787..2290962 - 1176 WP_001236265.1 BenE family transporter YdcO -
QC806_RS11330 (2291054) 2291054..2291590 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QC806_RS11335 (2291663) 2291663..2293624 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QC806_RS11340 (2293716) 2293716..2293946 - 231 WP_000494244.1 YncJ family protein -
QC806_RS11345 (2294168) 2294168..2294344 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QC806_RS11350 (2294390) 2294390..2294806 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QC806_RS11355 (2294885) 2294885..2296291 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QC806_RS11360 (2296536) 2296536..2297681 + 1146 WP_000047418.1 ABC transporter substrate-binding protein -
QC806_RS11365 (2297699) 2297699..2298712 + 1014 WP_000220393.1 ABC transporter ATP-binding protein -
QC806_RS11370 (2298713) 2298713..2299654 + 942 WP_152914928.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277107 WP_000813794.1 NZ_CP122507:2294168-2294344 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277107 WP_001270286.1 NZ_CP122507:2294390-2294806 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References