27710

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) SmuAT/-
Location 161633..162594 Replicon chromosome
Accession NC_017768
Organism Streptococcus mutans LJ23

Toxin (Protein)


Gene name smuT Uniprot ID -
Locus tag SMULJ23_RS00785 Protein ID WP_014677706.1
Coordinates 161633..162148 (+) Length 172 a.a.

Antitoxin (Protein)


Gene name smuA Uniprot ID -
Locus tag SMULJ23_RS00790 Protein ID WP_014677707.1
Coordinates 162148..162594 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMULJ23_RS00760 157050..157787 + 738 WP_002263001.1 MerR family transcriptional regulator -
SMULJ23_RS00765 157823..158815 - 993 WP_014677704.1 BtrH N-terminal domain-containing protein -
SMULJ23_RS00770 159004..159558 - 555 WP_002264861.1 PadR family transcriptional regulator -
SMULJ23_RS00775 159871..160617 + 747 WP_002264862.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
SMULJ23_RS00780 160641..161501 + 861 WP_014677705.1 DegV family protein -
SMULJ23_RS00785 161633..162148 + 516 WP_014677706.1 hypothetical protein Toxin
SMULJ23_RS00790 162148..162594 + 447 WP_014677707.1 hypothetical protein Antitoxin
SMULJ23_RS00795 162591..162785 + 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
SMULJ23_RS00800 163178..163624 + 447 WP_002262993.1 50S ribosomal protein L13 -
SMULJ23_RS00805 163649..164041 + 393 WP_002262992.1 30S ribosomal protein S9 -
SMULJ23_RS00810 164148..164465 - 318 WP_014677708.1 tyrosine-type recombinase/integrase -
SMULJ23_RS00815 164864..165532 + 669 WP_014677709.1 ArsR family transcriptional regulator -
SMULJ23_RS00820 165839..166151 + 313 Protein_143 thioredoxin -
SMULJ23_RS00825 166160..167080 + 921 WP_014677712.1 thioredoxin-disulfide reductase -
SMULJ23_RS00830 167080..167346 + 267 WP_148270968.1 hypothetical protein -
SMULJ23_RS00835 167347..167526 + 180 WP_014677714.1 type Z 30S ribosomal protein S14 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-272)

Antitoxin

AbiEi antitoxin C-terminal domain

(84-237)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 19590.27 Da        Isoelectric Point: 9.8654

>T27710 WP_014677706.1 NC_017768:161633-162148 [Streptococcus mutans LJ23]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCHSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFVVIFLVTA
YKTIQDKREGK

Download         Length: 516 bp

>T27710 NC_017768:161633-162148 [Streptococcus mutans LJ23]
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTCGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGCCACAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGTTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGGAAGTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16896.17 Da        Isoelectric Point: 9.7663

>AT27710 WP_014677707.1 NC_017768:162148-162594 [Streptococcus mutans LJ23]
MKMGKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKADLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Download         Length: 447 bp

>AT27710 NC_017768:162148-162594 [Streptococcus mutans LJ23]
ATGAAAATGGGAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACCTTTGGAAAGGCTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTCGGTCCTTTTGTTGACCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCTCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References