Detailed information of TA system TA027709

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 7021271..7021796
• Replicon: chromosome
• Accession: NC_017765
• Organism: Streptomyces hygroscopicus subsp. jinggangensis 5008

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SHJG_RS31090
• Protein ID: WP_041665481.1
• Coordinates: 7021271..7021534 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7G3UBC1
• Locus tag: SHJG_RS31095
• Protein ID: WP_030744248.1
• Coordinates: 7021527..7021796 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SHJG_RS47870	7017562..7018734	-	1173	WP_158506446.1	restriction endonuclease subunit S	-
SHJG_RS31085	7018767..7020419	-	1653	WP_014674729.1	type I restriction-modification system subunit M	-
SHJG_RS31090	7021271..7021534	-	264	WP_041665481.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SHJG_RS31095	7021527..7021796	-	270	WP_030744248.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SHJG_RS31100	7021925..7022389	-	465	WP_014674732.1	GNAT family N-acetyltransferase	-
SHJG_RS31105	7022595..7023725	-	1131	WP_014674733.1	DNA polymerase III subunit beta	-
SHJG_RS31110	7023809..7024312	-	504	WP_014674734.1	hypothetical protein	-
SHJG_RS31115	7024345..7025211	-	867	WP_014674735.1	amidinotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10017.46 Da
• Isoelectric Point: 7.1643

>T27709 WP_041665481.1 NC_017765:c7021534-7021271 [Streptomyces hygroscopicus subsp. jinggangensis 5008]
VSEYRTVFRPEAQAELRKIPCDMALRILAKLTELESDPLGFNSTALVSQPERRRLRVGDYRIVYTIDNGELVVWVVHVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T27709 NC_017765:c7021534-7021271 [Streptomyces hygroscopicus subsp. jinggangensis 5008]
GTGAGTGAATACCGAACCGTCTTCCGGCCGGAGGCACAGGCTGAGCTCCGGAAGATCCCTTGCGACATGGCCCTACGCAT
CCTGGCCAAACTGACCGAGCTGGAGAGCGACCCCCTCGGCTTCAACAGCACCGCGCTCGTGTCACAGCCAGAACGCCGTC
GACTGCGGGTCGGCGACTACCGGATCGTCTACACGATCGACAACGGAGAGCTCGTAGTGTGGGTCGTCCACGTCGGGCAT
CGCTCCACCGTTTACGACACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10258.73 Da
• Isoelectric Point: 4.7473

>AT27709 WP_030744248.1 NC_017765:c7021796-7021527 [Streptomyces hygroscopicus subsp. jinggangensis 5008]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT27709 NC_017765:c7021796-7021527 [Streptomyces hygroscopicus subsp. jinggangensis 5008]
ATGACGCAGCCGCTACCCATAGAGTCCATCCGCGACGTACGTGCGCACCTGGCCGAGGTCGTGGAGCGCGCCGATCGGGA
TGACGTGCCCACCGTGATCACCCGACGGGGCAAGCAAGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAACGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7G3UBC1