Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4381588..4382085 Replicon chromosome
Accession NZ_CP122503
Organism Escherichia coli strain W619

Toxin (Protein)


Gene name ghoT Uniprot ID A0A163EQM5
Locus tag QC808_RS21015 Protein ID WP_001672275.1
Coordinates 4381588..4381761 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QC808_RS21020 Protein ID WP_000398619.1
Coordinates 4381789..4382085 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC808_RS21005 (4378258) 4378258..4379715 + 1458 WP_021557456.1 dipeptide/tripeptide permease DtpC -
QC808_RS21010 (4379952) 4379952..4381469 + 1518 WP_001295074.1 lysine--tRNA ligase -
QC808_RS21015 (4381588) 4381588..4381761 - 174 WP_001672275.1 type V toxin-antitoxin system toxin GhoT Toxin
QC808_RS21020 (4381789) 4381789..4382085 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QC808_RS21025 (4382312) 4382312..4382584 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QC808_RS21030 (4382596) 4382596..4382826 - 231 WP_021557455.1 4Fe-4S mono-cluster protein YjdI -
QC808_RS21035 (4383007) 4383007..4384638 + 1632 WP_001216477.1 sensor histidine kinase -
QC808_RS21040 (4384635) 4384635..4385354 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6569.09 Da        Isoelectric Point: 10.2288

>T277088 WP_001672275.1 NZ_CP122503:c4381761-4381588 [Escherichia coli]
MALFSKILIFYVIGVNISFIIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277088 WP_000398619.1 NZ_CP122503:c4382085-4381789 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A163EQM5

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References