Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4284454..4285049 Replicon chromosome
Accession NZ_CP122503
Organism Escherichia coli strain W619

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QC808_RS20515 Protein ID WP_000239579.1
Coordinates 4284454..4284804 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QC808_RS20520 Protein ID WP_001223208.1
Coordinates 4284798..4285049 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC808_RS20495 (4279900) 4279900..4280922 - 1023 WP_001313531.1 ABC transporter permease -
QC808_RS20500 (4280936) 4280936..4282438 - 1503 WP_021557471.1 sugar ABC transporter ATP-binding protein -
QC808_RS20505 (4282578) 4282578..4283534 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QC808_RS20510 (4283844) 4283844..4284374 + 531 WP_000055072.1 inorganic diphosphatase -
QC808_RS20515 (4284454) 4284454..4284804 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QC808_RS20520 (4284798) 4284798..4285049 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QC808_RS20525 (4285262) 4285262..4285603 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QC808_RS20530 (4285606) 4285606..4289385 - 3780 WP_021557470.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T277087 WP_000239579.1 NZ_CP122503:c4284804-4284454 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT277087 WP_001223208.1 NZ_CP122503:c4285049-4284798 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References