Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4072795..4073345 Replicon chromosome
Accession NZ_CP122503
Organism Escherichia coli strain W619

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag QC808_RS19550 Protein ID WP_001160975.1
Coordinates 4072795..4073109 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID D3H431
Locus tag QC808_RS19555 Protein ID WP_000125565.1
Coordinates 4073112..4073345 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC808_RS19525 (4068470) 4068470..4069756 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
QC808_RS19530 (4069756) 4069756..4070745 + 990 WP_021556398.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
QC808_RS19535 (4070742) 4070742..4071563 + 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QC808_RS19540 (4071566) 4071566..4071943 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
QC808_RS19545 (4071950) 4071950..4072798 + 849 WP_021556397.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
QC808_RS19550 (4072795) 4072795..4073109 - 315 WP_001160975.1 CcdB family protein Toxin
QC808_RS19555 (4073112) 4073112..4073345 - 234 WP_000125565.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QC808_RS19560 (4073431) 4073431..4073910 - 480 WP_001487721.1 type 3 dihydrofolate reductase -
QC808_RS19565 (4074102) 4074102..4075964 - 1863 WP_040234481.1 glutathione-regulated potassium-efflux system protein KefC -
QC808_RS19570 (4075957) 4075957..4076487 - 531 WP_000600718.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
QC808_RS19575 (4076598) 4076598..4077929 - 1332 WP_001183198.1 MFS transporter -
QC808_RS19580 (4077987) 4077987..4078274 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T277086 WP_001160975.1 NZ_CP122503:c4073109-4072795 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8599.64 Da        Isoelectric Point: 6.9791

>AT277086 WP_000125565.1 NZ_CP122503:c4073345-4073112 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRRF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A090NGC7

References