Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 514141..514715 Replicon chromosome
Accession NC_017764
Organism Pasteurella multocida subsp. multocida str. 3480

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag NT08PM_RS02480 Protein ID WP_014667974.1
Coordinates 514141..514425 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag NT08PM_RS02485 Protein ID WP_014391174.1
Coordinates 514422..514715 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT08PM_RS02465 509603..511789 + 2187 WP_014667973.1 S8 family peptidase -
NT08PM_RS11235 512089..512414 + 326 Protein_473 hypothetical protein -
NT08PM_RS02475 512586..512847 + 262 Protein_474 hypothetical protein -
NT08PM_RS02480 514141..514425 + 285 WP_014667974.1 addiction module protein Toxin
NT08PM_RS02485 514422..514715 + 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
NT08PM_RS02490 515113..515790 - 678 WP_014667975.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
NT08PM_RS02495 515808..516275 - 468 WP_014391172.1 PTS sugar transporter subunit IIA -
NT08PM_RS02500 516320..518110 - 1791 WP_014667976.1 PTS ascorbate-specific subunit IIBC -
NT08PM_RS02505 518459..519550 + 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 512686..512847 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T27708 WP_014667974.1 NC_017764:514141-514425 [Pasteurella multocida subsp. multocida str. 3480]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T27708 NC_017764:514141-514425 [Pasteurella multocida subsp. multocida str. 3480]
GTGGGTCGGTTAAGGGAGGTAAAAAATTTATCCGCCAAAGCCGCTGTTCTTGCTCGTATTAACAGAGTAATGAATGGTAA
TTTGGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT27708 WP_014391174.1 NC_017764:514422-514715 [Pasteurella multocida subsp. multocida str. 3480]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp

>AT27708 NC_017764:514422-514715 [Pasteurella multocida subsp. multocida str. 3480]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAGCTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTACGCATTCATTAGGTATTAAACTTGTCCCAACGCACATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References