Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3494779..3495397 Replicon chromosome
Accession NZ_CP122499
Organism Escherichia coli strain W409

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QC809_RS17410 Protein ID WP_001291435.1
Coordinates 3495179..3495397 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QC809_RS17405 Protein ID WP_000344800.1
Coordinates 3494779..3495153 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC809_RS17395 (3489868) 3489868..3491061 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QC809_RS17400 (3491084) 3491084..3494233 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QC809_RS17405 (3494779) 3494779..3495153 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QC809_RS17410 (3495179) 3495179..3495397 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QC809_RS17415 (3495569) 3495569..3496120 + 552 WP_000102564.1 maltose O-acetyltransferase -
QC809_RS17420 (3496236) 3496236..3496706 + 471 WP_000136192.1 YlaC family protein -
QC809_RS17425 (3496870) 3496870..3498420 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QC809_RS17430 (3498462) 3498462..3498815 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QC809_RS17440 (3499194) 3499194..3499505 + 312 WP_000409911.1 MGMT family protein -
QC809_RS17445 (3499536) 3499536..3500108 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277057 WP_001291435.1 NZ_CP122499:3495179-3495397 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277057 WP_000344800.1 NZ_CP122499:3494779-3495153 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References