Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2400895..2402483 Replicon chromosome
Accession NZ_CP122499
Organism Escherichia coli strain W409

Toxin (Protein)


Gene name hipA Uniprot ID A0A2X9LRN3
Locus tag QC809_RS11960 Protein ID WP_021559062.1
Coordinates 2401161..2402483 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QC809_RS11955 Protein ID WP_001301023.1
Coordinates 2400895..2401161 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC809_RS11955 (2400895) 2400895..2401161 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QC809_RS11960 (2401161) 2401161..2402483 + 1323 WP_021559062.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QC809_RS11965 (2402795) 2402795..2403003 + 209 Protein_2341 AraC family transcriptional regulator -
QC809_RS11970 (2403258) 2403258..2404484 + 1227 Protein_2342 fimbria/pilus outer membrane usher protein -
QC809_RS11975 (2404498) 2404498..2404608 + 111 Protein_2343 type 1 fimbrial protein -
QC809_RS11980 (2404607) 2404607..2406448 + 1842 Protein_2344 acid resistance putative oxidoreductase YdeP -
QC809_RS11985 (2406696) 2406696..2406893 + 198 WP_000543394.1 two-component system connector SafA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2400895..2411021 10126


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49318.83 Da        Isoelectric Point: 8.7817

>T277056 WP_021559062.1 NZ_CP122499:2401161-2402483 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSSIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWRIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT277056 WP_001301023.1 NZ_CP122499:2400895-2401161 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X9LRN3

Antitoxin

Source ID Structure

References