Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 908790..909444 Replicon chromosome
Accession NZ_CP122499
Organism Escherichia coli strain W409

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QC809_RS04565 Protein ID WP_000244777.1
Coordinates 909037..909444 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QC809_RS04560 Protein ID WP_000354046.1
Coordinates 908790..909056 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC809_RS04535 (903959) 903959..904702 + 744 WP_000951964.1 SDR family oxidoreductase -
QC809_RS04540 (904759) 904759..906192 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
QC809_RS04545 (906237) 906237..906548 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
QC809_RS04550 (906712) 906712..907371 + 660 WP_000250272.1 hemolysin III family protein -
QC809_RS04555 (907567) 907567..908547 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QC809_RS04560 (908790) 908790..909056 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QC809_RS04565 (909037) 909037..909444 + 408 WP_000244777.1 protein YgfX Toxin
QC809_RS04570 (909484) 909484..910005 - 522 WP_001055874.1 flavodoxin FldB -
QC809_RS04575 (910117) 910117..911013 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QC809_RS04580 (911038) 911038..911748 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QC809_RS04585 (911754) 911754..913487 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T277048 WP_000244777.1 NZ_CP122499:909037-909444 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277048 WP_000354046.1 NZ_CP122499:908790-909056 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References