Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 30316..31114 Replicon plasmid unnamed1
Accession NZ_CP122497
Organism Escherichia coli strain a7

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag QC805_RS22700 Protein ID WP_072662620.1
Coordinates 30316..30837 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A141BRA2
Locus tag QC805_RS22705 Protein ID WP_001711191.1
Coordinates 30845..31114 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC805_RS22675 25435..28149 + 2715 WP_250147488.1 tail fiber protein -
QC805_RS22680 28149..28730 + 582 WP_087904721.1 tail fiber assembly protein -
QC805_RS22685 28864..29187 + 324 WP_001711185.1 hypothetical protein -
QC805_RS22690 29201..29893 + 693 WP_024172707.1 membrane protein -
QC805_RS22695 29896..30147 + 252 WP_023135660.1 hypothetical protein -
QC805_RS22700 30316..30837 - 522 WP_072662620.1 GNAT family N-acetyltransferase Toxin
QC805_RS22705 30845..31114 - 270 WP_001711191.1 DUF1778 domain-containing protein Antitoxin
QC805_RS22710 31434..32102 + 669 WP_000161228.1 division plane positioning ATPase MipZ -
QC805_RS22715 32108..32461 + 354 WP_160378290.1 hypothetical protein -
QC805_RS22720 32514..33281 - 768 WP_033870691.1 hypothetical protein -
QC805_RS22725 33564..34289 + 726 WP_087904723.1 hypothetical protein -
QC805_RS22730 34350..35690 + 1341 WP_023135655.1 DnaB-like helicase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..107494 107494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(48-149)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19359.18 Da        Isoelectric Point: 8.2462

>T277041 WP_072662620.1 NZ_CP122497:c30837-30316 [Escherichia coli]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLTNHLKRQHEGKILRAYVLCTKEEIPKVLGYYTLSGSCFEKETLPSKSQQ
KKVPYRNVPSITLGRLALDKSLQGQGLGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKARAFYKSLGFIQLVGNNDRSL
FYPTKSIEKLFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10054.53 Da        Isoelectric Point: 8.7353

>AT277041 WP_001711191.1 NZ_CP122497:c31114-30845 [Escherichia coli]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLSEESWNLVMDAISNPPAPNDKLKR
AANRLKSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A141BRA2

References