Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4106494..4106991 Replicon chromosome
Accession NZ_CP122496
Organism Escherichia coli strain a7

Toxin (Protein)


Gene name ghoT Uniprot ID -
Locus tag QC805_RS20380 Protein ID WP_023566341.1
Coordinates 4106494..4106667 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QC805_RS20385 Protein ID WP_000398619.1
Coordinates 4106695..4106991 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC805_RS20370 (4103164) 4103164..4104621 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QC805_RS20375 (4104858) 4104858..4106375 + 1518 WP_001295074.1 lysine--tRNA ligase -
QC805_RS20380 (4106494) 4106494..4106667 - 174 WP_023566341.1 type V toxin-antitoxin system toxin GhoT Toxin
QC805_RS20385 (4106695) 4106695..4106991 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QC805_RS20390 (4107218) 4107218..4107490 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QC805_RS20395 (4107502) 4107502..4107732 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QC805_RS20400 (4107913) 4107913..4109544 + 1632 WP_001216477.1 sensor histidine kinase -
QC805_RS20405 (4109541) 4109541..4110260 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6581.10 Da        Isoelectric Point: 9.9028

>T277040 WP_023566341.1 NZ_CP122496:c4106667-4106494 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISYEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277040 WP_000398619.1 NZ_CP122496:c4106991-4106695 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References