Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4010429..4011024 Replicon chromosome
Accession NZ_CP122496
Organism Escherichia coli strain a7

Toxin (Protein)


Gene name chpB Uniprot ID A0A827ISR3
Locus tag QC805_RS19885 Protein ID WP_061359519.1
Coordinates 4010429..4010779 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A240D6C8
Locus tag QC805_RS19890 Protein ID WP_001223212.1
Coordinates 4010773..4011024 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC805_RS19865 (4005878) 4005878..4006900 - 1023 WP_001301928.1 ABC transporter permease -
QC805_RS19870 (4006914) 4006914..4008416 - 1503 WP_000205807.1 sugar ABC transporter ATP-binding protein -
QC805_RS19875 (4008556) 4008556..4009512 - 957 WP_284613972.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QC805_RS19880 (4009822) 4009822..4010352 + 531 WP_000055070.1 inorganic diphosphatase -
QC805_RS19885 (4010429) 4010429..4010779 - 351 WP_061359519.1 endoribonuclease toxin ChpB Toxin
QC805_RS19890 (4010773) 4010773..4011024 - 252 WP_001223212.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QC805_RS19895 (4011236) 4011236..4011577 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QC805_RS19900 (4011580) 4011580..4015359 - 3780 WP_061359518.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12506.43 Da        Isoelectric Point: 6.4786

>T277039 WP_061359519.1 NZ_CP122496:c4010779-4010429 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARQAKRIGLAADEVVEEALLRLQAVVK

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9301.61 Da        Isoelectric Point: 4.6509

>AT277039 WP_001223212.1 NZ_CP122496:c4011024-4010773 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A827ISR3

Antitoxin

Source ID Structure
AlphaFold DB A0A240D6C8

References