Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3373454..3374072 Replicon chromosome
Accession NZ_CP122496
Organism Escherichia coli strain a7

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QC805_RS16655 Protein ID WP_001291435.1
Coordinates 3373854..3374072 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QC805_RS16650 Protein ID WP_000344800.1
Coordinates 3373454..3373828 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC805_RS16640 (3368543) 3368543..3369736 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QC805_RS16645 (3369759) 3369759..3372908 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QC805_RS16650 (3373454) 3373454..3373828 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QC805_RS16655 (3373854) 3373854..3374072 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QC805_RS16660 (3374244) 3374244..3374795 + 552 WP_000102564.1 maltose O-acetyltransferase -
QC805_RS16665 (3374911) 3374911..3375381 + 471 WP_000136192.1 YlaC family protein -
QC805_RS16670 (3375545) 3375545..3377095 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QC805_RS16675 (3377137) 3377137..3377490 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QC805_RS16685 (3377869) 3377869..3378180 + 312 WP_000409911.1 MGMT family protein -
QC805_RS16690 (3378211) 3378211..3378783 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277036 WP_001291435.1 NZ_CP122496:3373854-3374072 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277036 WP_000344800.1 NZ_CP122496:3373454-3373828 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References