Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2319712..2320350 Replicon chromosome
Accession NZ_CP122496
Organism Escherichia coli strain a7

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QC805_RS11290 Protein ID WP_000813794.1
Coordinates 2320174..2320350 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QC805_RS11285 Protein ID WP_001270286.1
Coordinates 2319712..2320128 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC805_RS11265 (2314864) 2314864..2315805 - 942 WP_001251313.1 ABC transporter permease -
QC805_RS11270 (2315806) 2315806..2316819 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
QC805_RS11275 (2316837) 2316837..2317982 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QC805_RS11280 (2318227) 2318227..2319633 - 1407 WP_284613874.1 PLP-dependent aminotransferase family protein -
QC805_RS11285 (2319712) 2319712..2320128 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QC805_RS11290 (2320174) 2320174..2320350 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QC805_RS11295 (2320572) 2320572..2320802 + 231 WP_000494244.1 YncJ family protein -
QC805_RS11300 (2320894) 2320894..2322855 - 1962 WP_284614154.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QC805_RS11305 (2322928) 2322928..2323464 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
QC805_RS11310 (2323556) 2323556..2324731 + 1176 WP_001236251.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2324771..2326036 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277035 WP_000813794.1 NZ_CP122496:c2320350-2320174 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277035 WP_001270286.1 NZ_CP122496:c2320128-2319712 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References