Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 69808..70330 Replicon plasmid unnamed3
Accession NZ_CP122495
Organism Escherichia coli strain a15

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag QC807_RS25980 Protein ID WP_000220561.1
Coordinates 70049..70330 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag QC807_RS25975 Protein ID WP_000121743.1
Coordinates 69808..70059 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC807_RS25955 (65931) 65931..66284 - 354 WP_024129958.1 DNA distortion polypeptide 3 -
QC807_RS25960 (66421) 66421..66867 - 447 WP_001074384.1 hypothetical protein -
QC807_RS25965 (66871) 66871..67713 - 843 WP_000435064.1 replication initiation protein -
QC807_RS25970 (67734) 67734..68573 - 840 WP_024129959.1 replication initiation protein -
QC807_RS25975 (69808) 69808..70059 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
QC807_RS25980 (70049) 70049..70330 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QC807_RS25985 (70569) 70569..70661 - 93 Protein_90 IS6 family transposase -
QC807_RS25995 (72035) 72035..72223 - 189 WP_000957857.1 hypothetical protein -
QC807_RS26000 (72453) 72453..72557 + 105 WP_032409716.1 hypothetical protein -
QC807_RS26005 (72686) 72686..72943 + 258 WP_000764642.1 hypothetical protein -
QC807_RS26010 (73001) 73001..73777 - 777 WP_000015958.1 site-specific integrase -
QC807_RS26015 (73774) 73774..74517 - 744 WP_000129823.1 hypothetical protein -
QC807_RS26020 (74568) 74568..74918 - 351 WP_000493378.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / oqxA / oqxB / aph(3')-IIa / blaTEM-1B / blaCTX-M-55 - 1..95954 95954


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T277024 WP_000220561.1 NZ_CP122495:70049-70330 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT277024 WP_000121743.1 NZ_CP122495:69808-70059 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References