Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4337338..4337933 Replicon chromosome
Accession NZ_CP122492
Organism Escherichia coli strain a15

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QC807_RS21095 Protein ID WP_000239579.1
Coordinates 4337338..4337688 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A4D0VVQ9
Locus tag QC807_RS21100 Protein ID WP_001223207.1
Coordinates 4337682..4337933 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC807_RS21075 (4332614) 4332614..4333636 - 1023 WP_001296689.1 ABC transporter permease -
QC807_RS21080 (4333650) 4333650..4335152 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
QC807_RS21085 (4335462) 4335462..4336418 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QC807_RS21090 (4336728) 4336728..4337258 + 531 WP_000055072.1 inorganic diphosphatase -
QC807_RS21095 (4337338) 4337338..4337688 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QC807_RS21100 (4337682) 4337682..4337933 - 252 WP_001223207.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QC807_RS21105 (4338146) 4338146..4338487 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QC807_RS21110 (4338490) 4338490..4342269 - 3780 WP_000060927.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T277011 WP_000239579.1 NZ_CP122492:c4337688-4337338 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.61 Da        Isoelectric Point: 4.4201

>AT277011 WP_001223207.1 NZ_CP122492:c4337933-4337682 [Escherichia coli]
MRITIKRWGNSAGMVIPNILMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A4D0VVQ9

References