277008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3557375..3558212 Replicon chromosome
Accession NZ_CP122492
Organism Escherichia coli strain a15

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QC807_RS17260 Protein ID WP_000227784.1
Coordinates 3557670..3558212 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QC807_RS17255 Protein ID WP_001297137.1
Coordinates 3557375..3557686 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC807_RS17230 (3552395) 3552395..3553342 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
QC807_RS17235 (3553364) 3553364..3555355 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QC807_RS17240 (3555345) 3555345..3555959 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QC807_RS17245 (3555959) 3555959..3556288 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QC807_RS17250 (3556300) 3556300..3557190 + 891 WP_000971336.1 heme o synthase -
QC807_RS17255 (3557375) 3557375..3557686 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QC807_RS17260 (3557670) 3557670..3558212 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QC807_RS17265 (3558268) 3558268..3559203 - 936 WP_001297127.1 tetratricopeptide repeat protein -
QC807_RS17270 (3559611) 3559611..3560975 + 1365 WP_001000975.1 MFS transporter -
QC807_RS17275 (3561103) 3561103..3561594 - 492 WP_001138904.1 nucleotide binding protein YajQ -
QC807_RS17280 (3561762) 3561762..3562673 + 912 WP_000705877.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T277008 WP_000227784.1 NZ_CP122492:3557670-3558212 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT277008 WP_001297137.1 NZ_CP122492:3557375-3557686 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References