Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3523286..3523904 Replicon chromosome
Accession NZ_CP122492
Organism Escherichia coli strain a15

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QC807_RS17090 Protein ID WP_001291435.1
Coordinates 3523686..3523904 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QC807_RS17085 Protein ID WP_000344800.1
Coordinates 3523286..3523660 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC807_RS17075 (3518375) 3518375..3519568 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QC807_RS17080 (3519591) 3519591..3522740 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QC807_RS17085 (3523286) 3523286..3523660 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QC807_RS17090 (3523686) 3523686..3523904 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QC807_RS17095 (3524075) 3524075..3524626 + 552 WP_000102578.1 maltose O-acetyltransferase -
QC807_RS17100 (3524742) 3524742..3525212 + 471 WP_000136192.1 YlaC family protein -
QC807_RS17105 (3525376) 3525376..3526926 + 1551 WP_001365886.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QC807_RS17110 (3526968) 3526968..3527321 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QC807_RS17120 (3527700) 3527700..3528011 + 312 WP_000409911.1 MGMT family protein -
QC807_RS17125 (3528042) 3528042..3528614 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277007 WP_001291435.1 NZ_CP122492:3523686-3523904 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277007 WP_000344800.1 NZ_CP122492:3523286-3523660 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References