Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1347395..1348020 Replicon chromosome
Accession NZ_CP122492
Organism Escherichia coli strain a15

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag QC807_RS06555 Protein ID WP_000911329.1
Coordinates 1347622..1348020 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QC807_RS06550 Protein ID WP_000450524.1
Coordinates 1347395..1347622 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC807_RS06525 (1343197) 1343197..1343667 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QC807_RS06530 (1343667) 1343667..1344239 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QC807_RS06535 (1344385) 1344385..1345263 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
QC807_RS06540 (1345280) 1345280..1346314 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QC807_RS06545 (1346527) 1346527..1347240 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QC807_RS06550 (1347395) 1347395..1347622 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QC807_RS06555 (1347622) 1347622..1348020 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
QC807_RS06560 (1348167) 1348167..1349030 + 864 WP_001267498.1 neutral zinc metallopeptidase -
QC807_RS06565 (1349045) 1349045..1351060 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
QC807_RS06570 (1351134) 1351134..1351832 + 699 WP_000679823.1 esterase -
QC807_RS06575 (1351942) 1351942..1352142 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T277000 WP_000911329.1 NZ_CP122492:1347622-1348020 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT277000 WP_000450524.1 NZ_CP122492:1347395-1347622 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References