Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2151041..2151570 Replicon chromosome
Accession NC_017763
Organism Staphylococcus aureus subsp. aureus HO 5096 0412

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SAEMRSA15_RS10900 Protein ID WP_000621175.1
Coordinates 2151041..2151403 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SAEMRSA15_RS10905 Protein ID WP_000948330.1
Coordinates 2151400..2151570 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAEMRSA15_RS10875 2148019..2148789 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
SAEMRSA15_RS10880 2148764..2149243 - 480 WP_001190825.1 anti-sigma B factor RsbW -
SAEMRSA15_RS10885 2149245..2149571 - 327 WP_001052491.1 anti-sigma factor antagonist -
SAEMRSA15_RS10890 2149691..2150692 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
SAEMRSA15_RS10900 2151041..2151403 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SAEMRSA15_RS10905 2151400..2151570 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SAEMRSA15_RS10910 2151655..2152803 - 1149 WP_001281141.1 alanine racemase -
SAEMRSA15_RS10915 2152869..2153228 - 360 WP_000581193.1 holo-ACP synthase -
SAEMRSA15_RS10920 2153232..2153723 - 492 WP_001205918.1 PH domain-containing protein -
SAEMRSA15_RS10925 2153710..2155293 - 1584 WP_001294624.1 PH domain-containing protein -
SAEMRSA15_RS10930 2155286..2155765 - 480 WP_001287080.1 hypothetical protein -
SAEMRSA15_RS10935 2155974..2156534 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T27700 WP_000621175.1 NC_017763:c2151403-2151041 [Staphylococcus aureus subsp. aureus HO 5096 0412]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T27700 NC_017763:c2151403-2151041 [Staphylococcus aureus subsp. aureus HO 5096 0412]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAATATAAATTGGATAAAGACTCAGTCATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTATTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT27700 WP_000948330.1 NC_017763:c2151570-2151400 [Staphylococcus aureus subsp. aureus HO 5096 0412]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp

>AT27700 NC_017763:c2151570-2151400 [Staphylococcus aureus subsp. aureus HO 5096 0412]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAATCATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References