Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4749007..4749523 Replicon chromosome
Accession NZ_CP122469
Organism Klebsiella pneumoniae subsp. pneumoniae strain IITJ_BC16

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag P9M40_RS23655 Protein ID WP_002886902.1
Coordinates 4749007..4749291 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag P9M40_RS23660 Protein ID WP_002886901.1
Coordinates 4749281..4749523 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9M40_RS23630 (4744423) 4744423..4744686 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
P9M40_RS23635 (4744816) 4744816..4744989 + 174 WP_032410138.1 hypothetical protein -
P9M40_RS23640 (4744992) 4744992..4745735 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
P9M40_RS23645 (4746092) 4746092..4748230 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
P9M40_RS23650 (4748539) 4748539..4749003 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P9M40_RS23655 (4749007) 4749007..4749291 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9M40_RS23660 (4749281) 4749281..4749523 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P9M40_RS23665 (4749601) 4749601..4751511 - 1911 WP_009486549.1 PRD domain-containing protein -
P9M40_RS23670 (4751534) 4751534..4752688 - 1155 WP_023302389.1 lactonase family protein -
P9M40_RS23675 (4752755) 4752755..4753495 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T276987 WP_002886902.1 NZ_CP122469:c4749291-4749007 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT276987 WP_002886901.1 NZ_CP122469:c4749523-4749281 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References