Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4663723..4664533 Replicon chromosome
Accession NZ_CP122469
Organism Klebsiella pneumoniae subsp. pneumoniae strain IITJ_BC16

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag P9M40_RS23275 Protein ID WP_014908042.1
Coordinates 4663723..4664256 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag P9M40_RS23280 Protein ID WP_023343051.1
Coordinates 4664267..4664533 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9M40_RS23270 (4662554) 4662554..4663675 + 1122 WP_012737335.1 cupin domain-containing protein -
P9M40_RS23275 (4663723) 4663723..4664256 - 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
P9M40_RS23280 (4664267) 4664267..4664533 - 267 WP_023343051.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
P9M40_RS23285 (4664636) 4664636..4666069 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
P9M40_RS23290 (4666059) 4666059..4666742 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
P9M40_RS23295 (4666915) 4666915..4668300 + 1386 WP_040182471.1 efflux transporter outer membrane subunit -
P9M40_RS23300 (4668318) 4668318..4668662 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T276986 WP_014908042.1 NZ_CP122469:c4664256-4663723 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT276986 WP_023343051.1 NZ_CP122469:c4664533-4664267 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References