Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2572094..2573682 Replicon chromosome
Accession NZ_CP122469
Organism Klebsiella pneumoniae subsp. pneumoniae strain IITJ_BC16

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag P9M40_RS12810 Protein ID WP_023301940.1
Coordinates 2572094..2573416 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag P9M40_RS12815 Protein ID WP_002904790.1
Coordinates 2573416..2573682 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9M40_RS12795 (2567150) 2567150..2569651 + 2502 WP_040182042.1 fimbria/pilus outer membrane usher protein -
P9M40_RS12800 (2569639) 2569639..2570643 + 1005 WP_009308876.1 fimbrial protein -
P9M40_RS12805 (2570785) 2570785..2572077 + 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
P9M40_RS12810 (2572094) 2572094..2573416 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
P9M40_RS12815 (2573416) 2573416..2573682 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P9M40_RS12820 (2573948) 2573948..2574274 - 327 WP_004143476.1 hydroxyisourate hydrolase -
P9M40_RS12825 (2574271) 2574271..2574771 - 501 WP_040182039.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
P9M40_RS12830 (2574749) 2574749..2576128 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
P9M40_RS12835 (2576474) 2576474..2577628 + 1155 WP_040182036.1 FAD-dependent urate hydroxylase HpxO -
P9M40_RS12840 (2577609) 2577609..2578532 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T276984 WP_023301940.1 NZ_CP122469:c2573416-2572094 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT276984 WP_002904790.1 NZ_CP122469:c2573682-2573416 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References