Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5225810..5226435 Replicon chromosome
Accession NZ_CP122461
Organism Klebsiella pneumoniae subsp. pneumoniae strain IITJ_U23

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P9M41_RS25925 Protein ID WP_040182550.1
Coordinates 5225810..5226193 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag P9M41_RS25930 Protein ID WP_004150355.1
Coordinates 5226193..5226435 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9M41_RS25910 (5223176) 5223176..5224078 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
P9M41_RS25915 (5224075) 5224075..5224710 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
P9M41_RS25920 (5224707) 5224707..5225636 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
P9M41_RS25925 (5225810) 5225810..5226193 - 384 WP_040182550.1 type II toxin-antitoxin system VapC family toxin Toxin
P9M41_RS25930 (5226193) 5226193..5226435 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
P9M41_RS25935 (5226640) 5226640..5227557 + 918 WP_023302328.1 alpha/beta hydrolase -
P9M41_RS25940 (5227571) 5227571..5228512 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
P9M41_RS25945 (5228557) 5228557..5228994 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
P9M41_RS25950 (5228991) 5228991..5229851 - 861 WP_004146232.1 virulence factor BrkB family protein -
P9M41_RS25955 (5229845) 5229845..5230444 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14376.67 Da        Isoelectric Point: 9.5352

>T276974 WP_040182550.1 NZ_CP122461:c5226193-5225810 [Klebsiella pneumoniae subsp. pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLKLITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT276974 WP_004150355.1 NZ_CP122461:c5226435-5226193 [Klebsiella pneumoniae subsp. pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References