Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4747968..4748484 Replicon chromosome
Accession NZ_CP122461
Organism Klebsiella pneumoniae subsp. pneumoniae strain IITJ_U23

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag P9M41_RS23665 Protein ID WP_002886902.1
Coordinates 4747968..4748252 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag P9M41_RS23670 Protein ID WP_002886901.1
Coordinates 4748242..4748484 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9M41_RS23640 (4743384) 4743384..4743647 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
P9M41_RS23645 (4743777) 4743777..4743950 + 174 WP_032410138.1 hypothetical protein -
P9M41_RS23650 (4743953) 4743953..4744696 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
P9M41_RS23655 (4745053) 4745053..4747191 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
P9M41_RS23660 (4747500) 4747500..4747964 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P9M41_RS23665 (4747968) 4747968..4748252 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9M41_RS23670 (4748242) 4748242..4748484 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P9M41_RS23675 (4748562) 4748562..4750472 - 1911 WP_009486549.1 PRD domain-containing protein -
P9M41_RS23680 (4750495) 4750495..4751649 - 1155 WP_023302389.1 lactonase family protein -
P9M41_RS23685 (4751716) 4751716..4752456 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T276972 WP_002886902.1 NZ_CP122461:c4748252-4747968 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT276972 WP_002886901.1 NZ_CP122461:c4748484-4748242 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References