Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2571062..2572650 Replicon chromosome
Accession NZ_CP122461
Organism Klebsiella pneumoniae subsp. pneumoniae strain IITJ_U23

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag P9M41_RS12805 Protein ID WP_023301940.1
Coordinates 2571062..2572384 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag P9M41_RS12810 Protein ID WP_002904790.1
Coordinates 2572384..2572650 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9M41_RS12790 (2566118) 2566118..2568619 + 2502 WP_040182042.1 fimbria/pilus outer membrane usher protein -
P9M41_RS12795 (2568607) 2568607..2569611 + 1005 WP_009308876.1 fimbrial protein -
P9M41_RS12800 (2569753) 2569753..2571045 + 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
P9M41_RS12805 (2571062) 2571062..2572384 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
P9M41_RS12810 (2572384) 2572384..2572650 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P9M41_RS12815 (2572916) 2572916..2573242 - 327 WP_004143476.1 hydroxyisourate hydrolase -
P9M41_RS12820 (2573239) 2573239..2573739 - 501 WP_040182039.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
P9M41_RS12825 (2573717) 2573717..2575096 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
P9M41_RS12830 (2575442) 2575442..2576596 + 1155 WP_040182036.1 FAD-dependent urate hydroxylase HpxO -
P9M41_RS12835 (2576577) 2576577..2577500 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T276969 WP_023301940.1 NZ_CP122461:c2572384-2571062 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT276969 WP_002904790.1 NZ_CP122461:c2572650-2572384 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References