Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 792136..792793 Replicon chromosome
Accession NZ_CP122461
Organism Klebsiella pneumoniae subsp. pneumoniae strain IITJ_U23

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag P9M41_RS03955 Protein ID WP_002916310.1
Coordinates 792383..792793 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P9M41_RS03950 Protein ID WP_002916312.1
Coordinates 792136..792402 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9M41_RS03925 (787292) 787292..788725 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
P9M41_RS03930 (788844) 788844..789572 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
P9M41_RS03935 (789622) 789622..789933 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
P9M41_RS03940 (790097) 790097..790756 + 660 WP_002916317.1 hemolysin III family protein -
P9M41_RS03945 (790907) 790907..791890 - 984 WP_279751822.1 tRNA-modifying protein YgfZ -
P9M41_RS03950 (792136) 792136..792402 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P9M41_RS03955 (792383) 792383..792793 + 411 WP_002916310.1 protein YgfX Toxin
P9M41_RS03960 (792800) 792800..793321 - 522 WP_004144730.1 flavodoxin FldB -
P9M41_RS03965 (793422) 793422..794318 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P9M41_RS03970 (794341) 794341..795054 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P9M41_RS03975 (795060) 795060..796793 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T276964 WP_002916310.1 NZ_CP122461:792383-792793 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT276964 WP_002916312.1 NZ_CP122461:792136-792402 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References