Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4164273..4164916 Replicon chromosome
Accession NZ_CP122457
Organism Salmonella enterica subsp. enterica strain TZ282

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag QCX26_RS20035 Protein ID WP_000048134.1
Coordinates 4164500..4164916 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag QCX26_RS20030 Protein ID WP_001261294.1
Coordinates 4164273..4164503 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCX26_RS20020 (4161288) 4161288..4163426 + 2139 WP_000187822.1 anaerobic ribonucleoside-triphosphate reductase -
QCX26_RS20025 (4163642) 4163642..4164106 + 465 WP_076736138.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QCX26_RS20030 (4164273) 4164273..4164503 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QCX26_RS20035 (4164500) 4164500..4164916 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
QCX26_RS20040 (4164977) 4164977..4166890 - 1914 WP_139763623.1 BglG family transcription antiterminator -
QCX26_RS20045 (4166907) 4166907..4167647 - 741 WP_079984068.1 KDGP aldolase family protein -
QCX26_RS20050 (4167644) 4167644..4168762 - 1119 WP_079984067.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
QCX26_RS20055 (4168746) 4168746..4169879 - 1134 WP_079984066.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T276957 WP_000048134.1 NZ_CP122457:4164500-4164916 [Salmonella enterica subsp. enterica]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT276957 WP_001261294.1 NZ_CP122457:4164273-4164503 [Salmonella enterica subsp. enterica]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References