Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3412382..3413002 Replicon chromosome
Accession NZ_CP122457
Organism Salmonella enterica subsp. enterica strain TZ282

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QCX26_RS16495 Protein ID WP_001280991.1
Coordinates 3412784..3413002 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag QCX26_RS16490 Protein ID WP_000344807.1
Coordinates 3412382..3412756 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCX26_RS16480 (3407521) 3407521..3408714 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QCX26_RS16485 (3408737) 3408737..3411886 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
QCX26_RS16490 (3412382) 3412382..3412756 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
QCX26_RS16495 (3412784) 3412784..3413002 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QCX26_RS16500 (3413181) 3413181..3413732 + 552 WP_001278792.1 maltose O-acetyltransferase -
QCX26_RS16505 (3413849) 3413849..3414319 + 471 WP_000136181.1 YlaC family protein -
QCX26_RS16510 (3414375) 3414375..3414515 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QCX26_RS16515 (3414521) 3414521..3414781 - 261 WP_254520504.1 type B 50S ribosomal protein L31 -
QCX26_RS16520 (3415006) 3415006..3416556 + 1551 WP_154023596.1 EAL domain-containing protein -
QCX26_RS16530 (3416787) 3416787..3417176 + 390 WP_000961285.1 MGMT family protein -
QCX26_RS16535 (3417209) 3417209..3417778 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T276953 WP_001280991.1 NZ_CP122457:3412784-3413002 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT276953 WP_000344807.1 NZ_CP122457:3412382-3412756 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References