Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1568786..1569404 Replicon chromosome
Accession NZ_CP122454
Organism Escherichia coli strain 82.0311

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QBY76_RS07535 Protein ID WP_001291435.1
Coordinates 1568786..1569004 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QBY76_RS07540 Protein ID WP_000344800.1
Coordinates 1569030..1569404 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY76_RS07500 (1564074) 1564074..1564646 + 573 WP_087597809.1 YbaY family lipoprotein -
QBY76_RS07505 (1564677) 1564677..1564988 - 312 WP_000409908.1 MGMT family protein -
QBY76_RS07515 (1565367) 1565367..1565720 + 354 WP_000878140.1 DUF1428 domain-containing protein -
QBY76_RS07520 (1565762) 1565762..1567312 - 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QBY76_RS07525 (1567476) 1567476..1567946 - 471 WP_000136192.1 YlaC family protein -
QBY76_RS07530 (1568062) 1568062..1568613 - 552 WP_000102539.1 maltose O-acetyltransferase -
QBY76_RS07535 (1568786) 1568786..1569004 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QBY76_RS07540 (1569030) 1569030..1569404 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QBY76_RS07545 (1569950) 1569950..1573099 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QBY76_RS07550 (1573122) 1573122..1574315 - 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T276924 WP_001291435.1 NZ_CP122454:c1569004-1568786 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT276924 WP_000344800.1 NZ_CP122454:c1569404-1569030 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References