Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 650402..650899 Replicon chromosome
Accession NZ_CP122454
Organism Escherichia coli strain 82.0311

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QBY76_RS03105 Protein ID WP_001173343.1
Coordinates 650726..650899 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QBY76_RS03100 Protein ID WP_001312331.1
Coordinates 650402..650698 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY76_RS03080 (647131) 647131..647850 - 720 WP_000611291.1 two-component system response regulator DcuR -
QBY76_RS03085 (647847) 647847..649478 - 1632 WP_001216466.1 sensor histidine kinase -
QBY76_RS03090 (649659) 649659..649889 + 231 WP_001683478.1 4Fe-4S mono-cluster protein YjdI -
QBY76_RS03095 (649901) 649901..650173 + 273 WP_097738063.1 GNAT family N-acetyltransferase -
QBY76_RS03100 (650402) 650402..650698 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QBY76_RS03105 (650726) 650726..650899 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QBY76_RS03110 (651018) 651018..652535 - 1518 WP_000003805.1 lysine--tRNA ligase -
QBY76_RS03115 (652772) 652772..654229 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 650402..659753 9351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T276920 WP_001173343.1 NZ_CP122454:650726-650899 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT276920 WP_001312331.1 NZ_CP122454:650402-650698 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References