Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4690077..4690574 Replicon chromosome
Accession NZ_CP122451
Organism Escherichia coli strain 82.0312

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QBY78_RS22890 Protein ID WP_001173343.1
Coordinates 4690077..4690250 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QBY78_RS22895 Protein ID WP_001312331.1
Coordinates 4690278..4690574 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY78_RS22880 (4686747) 4686747..4688204 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QBY78_RS22885 (4688441) 4688441..4689958 + 1518 WP_000003805.1 lysine--tRNA ligase -
QBY78_RS22890 (4690077) 4690077..4690250 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QBY78_RS22895 (4690278) 4690278..4690574 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QBY78_RS22900 (4690803) 4690803..4691075 - 273 WP_097738063.1 GNAT family N-acetyltransferase -
QBY78_RS22905 (4691087) 4691087..4691317 - 231 WP_001683478.1 4Fe-4S mono-cluster protein YjdI -
QBY78_RS22910 (4691498) 4691498..4693129 + 1632 WP_001216466.1 sensor histidine kinase -
QBY78_RS22915 (4693126) 4693126..4693845 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T276914 WP_001173343.1 NZ_CP122451:c4690250-4690077 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT276914 WP_001312331.1 NZ_CP122451:c4690574-4690278 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References