Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3771605..3772223 Replicon chromosome
Accession NZ_CP122451
Organism Escherichia coli strain 82.0312

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QBY78_RS18460 Protein ID WP_001291435.1
Coordinates 3772005..3772223 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QBY78_RS18455 Protein ID WP_000344800.1
Coordinates 3771605..3771979 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY78_RS18445 (3766694) 3766694..3767887 + 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QBY78_RS18450 (3767910) 3767910..3771059 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QBY78_RS18455 (3771605) 3771605..3771979 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QBY78_RS18460 (3772005) 3772005..3772223 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QBY78_RS18465 (3772396) 3772396..3772947 + 552 WP_000102539.1 maltose O-acetyltransferase -
QBY78_RS18470 (3773063) 3773063..3773533 + 471 WP_000136192.1 YlaC family protein -
QBY78_RS18475 (3773697) 3773697..3775247 + 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QBY78_RS18480 (3775289) 3775289..3775642 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QBY78_RS18490 (3776021) 3776021..3776332 + 312 WP_000409908.1 MGMT family protein -
QBY78_RS18495 (3776363) 3776363..3776935 - 573 WP_087597809.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T276910 WP_001291435.1 NZ_CP122451:3772005-3772223 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT276910 WP_000344800.1 NZ_CP122451:3771605-3771979 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References