Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2501586..2503174 Replicon chromosome
Accession NZ_CP122451
Organism Escherichia coli strain 82.0312

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag QBY78_RS11930 Protein ID WP_001125475.1
Coordinates 2501852..2503174 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBY78_RS11925 Protein ID WP_001332145.1
Coordinates 2501586..2501852 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY78_RS11910 (2497954) 2497954..2499405 + 1452 WP_000854633.1 tagaturonate reductase -
QBY78_RS11915 (2499602) 2499602..2500516 + 915 WP_049212422.1 bestrophin family protein -
QBY78_RS11920 (2500520) 2500520..2501278 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
QBY78_RS11925 (2501586) 2501586..2501852 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QBY78_RS11930 (2501852) 2501852..2503174 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QBY78_RS11935 (2503800) 2503800..2504189 - 390 WP_283154900.1 hypothetical protein -
QBY78_RS11940 (2504288) 2504288..2504734 - 447 WP_000527682.1 helix-turn-helix transcriptional regulator -
QBY78_RS11945 (2504906) 2504906..2505958 + 1053 WP_000568107.1 phage/plasmid replication protein, II/X family -
QBY78_RS11950 (2505970) 2505970..2506287 + 318 WP_000073835.1 DNA-binding protein -
QBY78_RS11955 (2506290) 2506290..2506541 + 252 WP_283154901.1 hypothetical protein -
QBY78_RS11960 (2506576) 2506576..2506809 + 234 WP_000473544.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T276907 WP_001125475.1 NZ_CP122451:2501852-2503174 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT276907 WP_001332145.1 NZ_CP122451:2501586-2501852 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References