Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 939854..940508 Replicon chromosome
Accession NZ_CP122451
Organism Escherichia coli strain 82.0312

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QBY78_RS04610 Protein ID WP_000244781.1
Coordinates 940101..940508 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QBY78_RS04605 Protein ID WP_000354046.1
Coordinates 939854..940120 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY78_RS04585 (935942) 935942..937375 - 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -
QBY78_RS04590 (937420) 937420..937731 + 312 WP_001182959.1 N(4)-acetylcytidine aminohydrolase -
QBY78_RS04595 (937895) 937895..938554 + 660 WP_000250274.1 hemolysin III family protein -
QBY78_RS04600 (938631) 938631..939611 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
QBY78_RS04605 (939854) 939854..940120 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QBY78_RS04610 (940101) 940101..940508 + 408 WP_000244781.1 protein YgfX Toxin
QBY78_RS04615 (940548) 940548..941069 - 522 WP_001055874.1 flavodoxin FldB -
QBY78_RS04620 (941181) 941181..942077 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QBY78_RS04625 (942102) 942102..942812 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QBY78_RS04630 (942818) 942818..944551 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T276898 WP_000244781.1 NZ_CP122451:940101-940508 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT276898 WP_000354046.1 NZ_CP122451:939854-940120 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References