Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3906..4465 Replicon plasmid p2
Accession NZ_CP122450
Organism Escherichia coli strain 85.0412

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag QBY77_RS25355 Protein ID WP_000421259.1
Coordinates 4190..4465 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A3UPL5
Locus tag QBY77_RS25350 Protein ID WP_044864180.1
Coordinates 3906..4190 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY77_RS25330 (1) 1..858 + 858 WP_050947965.1 incFII family plasmid replication initiator RepA -
QBY77_RS25335 (1868) 1868..2131 + 264 WP_016241862.1 hypothetical protein -
QBY77_RS25340 (2121) 2121..2420 + 300 WP_016241863.1 type II toxin-antitoxin system RelE/ParE family toxin -
QBY77_RS25345 (2561) 2561..3538 + 978 WP_050947967.1 DUF4238 domain-containing protein -
QBY77_RS25350 (3906) 3906..4190 + 285 WP_044864180.1 ribbon-helix-helix domain-containing protein Antitoxin
QBY77_RS25355 (4190) 4190..4465 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBY77_RS25360 (4563) 4563..4766 + 204 Protein_6 hypothetical protein -
QBY77_RS25365 (5026) 5026..8157 + 3132 WP_044864181.1 hypothetical protein -
QBY77_RS25370 (8502) 8502..9338 - 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / aph(3'')-Ib / tet(B) / blaTEM-1B - 1..91257 91257


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T276893 WP_000421259.1 NZ_CP122450:4190-4465 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10560.00 Da        Isoelectric Point: 5.6558

>AT276893 WP_044864180.1 NZ_CP122450:3906-4190 [Escherichia coli]
MQMKNNTAQTTKVITAHVPLPMADKIDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLNTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB A0A2A3UPL5

References