Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4602355..4602852 Replicon chromosome
Accession NZ_CP122448
Organism Escherichia coli strain 85.0412

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QBY77_RS22275 Protein ID WP_001173343.1
Coordinates 4602355..4602528 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QBY77_RS22280 Protein ID WP_001312331.1
Coordinates 4602556..4602852 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY77_RS22265 (4599025) 4599025..4600482 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QBY77_RS22270 (4600719) 4600719..4602236 + 1518 WP_000003805.1 lysine--tRNA ligase -
QBY77_RS22275 (4602355) 4602355..4602528 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QBY77_RS22280 (4602556) 4602556..4602852 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QBY77_RS22285 (4603081) 4603081..4603353 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QBY77_RS22290 (4603365) 4603365..4603595 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
QBY77_RS22295 (4603776) 4603776..4605407 + 1632 WP_001216466.1 sensor histidine kinase -
QBY77_RS22300 (4605404) 4605404..4606123 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T276890 WP_001173343.1 NZ_CP122448:c4602528-4602355 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT276890 WP_001312331.1 NZ_CP122448:c4602852-4602556 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References