Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 833207..833684 Replicon chromosome
Accession NC_017763
Organism Staphylococcus aureus subsp. aureus HO 5096 0412

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAEMRSA15_RS03935 Protein ID WP_000052076.1
Coordinates 833207..833395 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAEMRSA15_RS03940 Protein ID WP_001059690.1
Coordinates 833424..833684 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAEMRSA15_RS03905 829197..829718 + 522 WP_000824488.1 hypothetical protein -
SAEMRSA15_RS03910 830059..830745 + 687 WP_001670297.1 thermonuclease family protein -
SAEMRSA15_RS03915 831102..831302 + 201 WP_001059082.1 cold-shock protein -
SAEMRSA15_RS03920 831798..832016 - 219 WP_000005876.1 hypothetical protein -
SAEMRSA15_RS03925 832078..832362 - 285 WP_001004395.1 hypothetical protein -
SAEMRSA15_RS03930 832450..833019 - 570 WP_001106646.1 hypothetical protein -
SAEMRSA15_RS03935 833207..833395 - 189 WP_000052076.1 hypothetical protein Toxin
SAEMRSA15_RS03940 833424..833684 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAEMRSA15_RS03945 834024..834227 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAEMRSA15_RS03950 834224..834460 - 237 WP_000368687.1 hypothetical protein -
SAEMRSA15_RS03955 834685..835266 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SAEMRSA15_RS03960 835339..835956 - 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
SAEMRSA15_RS03965 836110..836604 - 495 WP_000590539.1 GNAT family N-acetyltransferase -
SAEMRSA15_RS03970 837003..837425 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SAEMRSA15_RS03975 837573..838289 + 717 WP_000150015.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T27688 WP_000052076.1 NC_017763:c833395-833207 [Staphylococcus aureus subsp. aureus HO 5096 0412]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T27688 NC_017763:c833395-833207 [Staphylococcus aureus subsp. aureus HO 5096 0412]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTTACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT27688 WP_001059690.1 NC_017763:c833684-833424 [Staphylococcus aureus subsp. aureus HO 5096 0412]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT27688 NC_017763:c833684-833424 [Staphylococcus aureus subsp. aureus HO 5096 0412]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References