Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 292032..292645 Replicon chromosome
Accession NC_017761
Organism Helicobacter cinaedi PAGU611

Toxin (Protein)


Gene name vapC Uniprot ID A0A809N4D6
Locus tag HCN_RS01460 Protein ID WP_014666338.1
Coordinates 292032..292433 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID I7HE84
Locus tag HCN_RS01465 Protein ID WP_002957229.1
Coordinates 292421..292645 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCN_RS11410 288778..288936 + 159 WP_158309886.1 hypothetical protein -
HCN_RS01440 288986..290647 - 1662 WP_014666333.1 DUF262 domain-containing HNH endonuclease family protein -
HCN_RS11600 290637..290807 - 171 WP_014666334.1 hypothetical protein -
HCN_RS10820 290841..291048 - 208 Protein_287 hypothetical protein -
HCN_RS01450 291196..291384 - 189 WP_014666336.1 hypothetical protein -
HCN_RS01455 291459..291830 - 372 WP_014666337.1 hypothetical protein -
HCN_RS01460 292032..292433 - 402 WP_014666338.1 type II toxin-antitoxin system VapC family toxin Toxin
HCN_RS01465 292421..292645 - 225 WP_002957229.1 hypothetical protein Antitoxin
HCN_RS10920 292808..293719 + 912 WP_104716839.1 WYL domain-containing protein -
HCN_RS01480 293879..294553 + 675 WP_014666340.1 hypothetical protein -
HCN_RS01485 294602..295975 + 1374 WP_014666341.1 U32 family peptidase -
HCN_RS01490 295979..296878 - 900 WP_014667511.1 ATP-binding cassette domain-containing protein -
HCN_RS01495 296875..297552 - 678 WP_172580125.1 molybdate ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15295.74 Da        Isoelectric Point: 7.1618

>T27687 WP_014666338.1 NC_017761:c292433-292032 [Helicobacter cinaedi PAGU611]
MAKIMLDTNICIYIINNKPQYIKDRFLQYRIGDIAISSISVSELYFGVEKSQYKEANTNALNTFLTHLEVIDFTHKEALT
YAKIRADLEYKKSLIGAIDMLISAVALANDLTLITDNTKEFQRVKNLKIENWV

Download         Length: 402 bp

>T27687 NC_017761:c292433-292032 [Helicobacter cinaedi PAGU611]
ATGGCAAAAATAATGCTTGATACAAATATATGTATTTATATTATCAATAATAAACCGCAATATATTAAAGATAGATTTTT
ACAATACAGAATAGGCGATATTGCTATAAGCTCTATCAGTGTATCTGAATTATACTTTGGTGTAGAAAAATCTCAATATA
AAGAAGCAAATACAAATGCTCTTAATACATTCCTAACACACCTTGAAGTAATAGATTTCACACATAAAGAAGCACTTACA
TATGCAAAAATTAGAGCAGATTTAGAATACAAAAAGTCTCTCATAGGTGCTATAGATATGCTTATTTCAGCGGTAGCTCT
TGCAAATGATTTAACACTTATTACAGATAACACAAAAGAATTTCAAAGAGTTAAGAATCTAAAAATAGAAAATTGGGTGT
GA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8508.80 Da        Isoelectric Point: 9.9129

>AT27687 WP_002957229.1 NC_017761:c292645-292421 [Helicobacter cinaedi PAGU611]
MKAKVFKSGNSLAIRLPKALNLTKDCEFNIKQINNNIVLTPANSNWDSLFSAIDSFKGEIKRDELILQDREWQK

Download         Length: 225 bp

>AT27687 NC_017761:c292645-292421 [Helicobacter cinaedi PAGU611]
ATGAAAGCAAAAGTATTTAAAAGTGGCAATTCACTTGCGATAAGATTGCCAAAGGCATTGAATCTTACTAAGGATTGCGA
GTTTAATATAAAACAAATAAACAATAACATTGTTTTAACGCCTGCTAACTCAAATTGGGATAGTCTATTTTCAGCAATAG
ATAGCTTTAAGGGCGAAATAAAGCGAGATGAACTTATATTGCAGGATAGAGAATGGCAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A809N4D6

Antitoxin

Source ID Structure
AlphaFold DB A0A809NJV2

References