Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 993375..994029 Replicon chromosome
Accession NZ_CP122448
Organism Escherichia coli strain 85.0412

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QBY77_RS04895 Protein ID WP_000244765.1
Coordinates 993622..994029 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QBY77_RS04890 Protein ID WP_000354046.1
Coordinates 993375..993641 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBY77_RS04870 (989463) 989463..990896 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
QBY77_RS04875 (990941) 990941..991252 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QBY77_RS04880 (991416) 991416..992075 + 660 WP_000250274.1 hemolysin III family protein -
QBY77_RS04885 (992152) 992152..993132 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QBY77_RS04890 (993375) 993375..993641 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QBY77_RS04895 (993622) 993622..994029 + 408 WP_000244765.1 protein YgfX Toxin
QBY77_RS04900 (994069) 994069..994590 - 522 WP_001055874.1 flavodoxin FldB -
QBY77_RS04905 (994702) 994702..995598 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QBY77_RS04910 (995623) 995623..996333 + 711 WP_000715229.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QBY77_RS04915 (996339) 996339..998072 + 1734 WP_283154793.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T276869 WP_000244765.1 NZ_CP122448:993622-994029 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT276869 WP_000354046.1 NZ_CP122448:993375-993641 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References