Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3221423..3222043 Replicon chromosome
Accession NZ_CP122442
Organism Enterobacter ludwigii strain I9455333cz

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag QCL67_RS15800 Protein ID WP_014168902.1
Coordinates 3221825..3222043 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag QCL67_RS15795 Protein ID WP_020885187.1
Coordinates 3221423..3221797 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCL67_RS15785 (QCL67_15785) 3216549..3217742 + 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QCL67_RS15790 (QCL67_15790) 3217765..3220911 + 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit AcrB -
QCL67_RS15795 (QCL67_15795) 3221423..3221797 + 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
QCL67_RS15800 (QCL67_15800) 3221825..3222043 + 219 WP_014168902.1 HHA domain-containing protein Toxin
QCL67_RS15805 (QCL67_15805) 3222253..3222804 + 552 WP_020885188.1 maltose O-acetyltransferase -
QCL67_RS15810 (QCL67_15810) 3222922..3223389 + 468 WP_279795482.1 YlaC family protein -
QCL67_RS15815 (QCL67_15815) 3223361..3224821 - 1461 WP_040016798.1 PLP-dependent aminotransferase family protein -
QCL67_RS15820 (QCL67_15820) 3224922..3225632 + 711 WP_014168897.1 GNAT family protein -
QCL67_RS15825 (QCL67_15825) 3225629..3225769 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
QCL67_RS15830 (QCL67_15830) 3225772..3226032 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T276860 WP_014168902.1 NZ_CP122442:3221825-3222043 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT276860 WP_020885187.1 NZ_CP122442:3221423-3221797 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References