Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4932675..4933336 Replicon chromosome
Accession NZ_CP122407
Organism Rugamonas sp. DEMB1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QC826_RS22790 Protein ID WP_279762587.1
Coordinates 4933151..4933336 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QC826_RS22785 Protein ID WP_093387724.1
Coordinates 4932675..4933088 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC826_RS22770 (QC826_22770) 4928312..4931269 + 2958 WP_279762585.1 heparinase II/III family protein -
QC826_RS22775 (QC826_22775) 4931336..4932310 - 975 WP_093387458.1 LysR family transcriptional regulator -
QC826_RS22780 (QC826_22780) 4932413..4932610 + 198 WP_279762586.1 hypothetical protein -
QC826_RS22785 (QC826_22785) 4932675..4933088 - 414 WP_093387724.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QC826_RS22790 (QC826_22790) 4933151..4933336 - 186 WP_279762587.1 type II toxin-antitoxin system HicA family toxin Toxin
QC826_RS22795 (QC826_22795) 4933690..4934898 - 1209 WP_279762588.1 MFS transporter -
QC826_RS22800 (QC826_22800) 4934993..4936138 + 1146 WP_279762589.1 acyltransferase -
QC826_RS22805 (QC826_22805) 4936113..4936895 - 783 WP_279762590.1 flagellar brake protein -
QC826_RS22810 (QC826_22810) 4937198..4937839 + 642 WP_093387465.1 uridine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4932675..4941937 9262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-81)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6999.08 Da        Isoelectric Point: 11.1572

>T276850 WP_279762587.1 NZ_CP122407:c4933336-4933151 [Rugamonas sp. DEMB1]
VKQSEFRRWLGEQGATFKDGTNHLKVYLNGKQTVMPRHPSHEIGERLRQAVLKQLGLKTGK

Download         Length: 186 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14955.28 Da        Isoelectric Point: 4.7324

>AT276850 WP_093387724.1 NZ_CP122407:c4933088-4932675 [Rugamonas sp. DEMB1]
MRYPVKIEQDGEGWFASVPAIPEALTSGPSAEAALAMAKDALITSMDFYFEDGRPVPLPGDIAEGEYHVDLPASMWAKVL
LLNEMLAQQKRPTDLARLLGAKLQDVQRLFDLAHPTKIDKVEQALNALGKHLVMAAS

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References