Detailed information of TA system TA027684

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 911832..912438
• Replicon: chromosome
• Accession: NC_017742
• Organism: Helicobacter pylori PeCan18

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M3LAD1
• Locus tag: HPPC18_RS04325
• Protein ID: WP_000916158.1
• Coordinates: 911832..912092 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M3LI72
• Locus tag: HPPC18_RS04330
• Protein ID: WP_001134112.1
• Coordinates: 912073..912438 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPPC18_RS04285	907037..907804	-	768	WP_000242348.1	ABC transporter ATP-binding protein	-
HPPC18_RS04290	907804..908784	-	981	WP_000921476.1	iron ABC transporter permease	-
HPPC18_RS04295	908777..909625	-	849	WP_000538086.1	SDR family oxidoreductase	-
HPPC18_RS04300	909765..910289	+	525	WP_001135628.1	acyl-CoA thioesterase	-
HPPC18_RS04305	910393..910662	-	270	WP_014662389.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
HPPC18_RS04310	910671..910952	-	282	WP_000917055.1	hypothetical protein	-
HPPC18_RS04315	911293..911523	+	231	WP_041200944.1	hypothetical protein	-
HPPC18_RS04320	911536..911784	-	249	WP_001134101.1	hypothetical protein	-
HPPC18_RS04325	911832..912092	-	261	WP_000916158.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPPC18_RS04330	912073..912438	-	366	WP_001134112.1	hypothetical protein	Antitoxin
HPPC18_RS04335	913186..915435	-	2250	WP_000716257.1	Hop family adhesin BabA	-
HPPC18_RS08150	916249..916650	-	402	WP_080024922.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10096.03 Da
• Isoelectric Point: 9.5330

>T27684 WP_000916158.1 NC_017742:c912092-911832 [Helicobacter pylori PeCan18]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILRKKEPLPPPFKDHALKGVWKPYRECHIKPDILLVYLVKDDELILLRLG
SHSELF

Nucleotide

• Length: 261 bp

>T27684 NC_017742:c912092-911832 [Helicobacter pylori PeCan18]
GTGTTGAAGCTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAAGAAAGAAAGAACCGCTACCCCCACCATTTAAAGATCACGCTTTAAAGGGGGTTTGGAAGCCTT
ATAGAGAATGCCACATTAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGGCTAGGC
AGTCATAGCGAGCTGTTTTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 14303.17 Da
• Isoelectric Point: 6.9617

>AT27684 WP_001134112.1 NC_017742:c912438-912073 [Helicobacter pylori PeCan18]
MPNTTNKDYTKYSEKQLFNLMNKKEQEIEKLKRDRAYLEKKMAKELEKKDKGFTIKLEELNKILQEINKRANDCCFGHET
PNIETQQAMREADNKETDLFVEDFSSYSNERKKALGVEAQS

Nucleotide

• Length: 366 bp

>AT27684 NC_017742:c912438-912073 [Helicobacter pylori PeCan18]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCGAAAAACAGCTTTTTAATCTCATGAATAAAAAAGAACAAGA
AATTGAAAAGCTAAAAAGGGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAGCTAGAGAAAAAAGATAAAGGTTTCA
CTATCAAGTTAGAAGAATTGAACAAAATCTTACAAGAAATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACC
CCAAATATTGAAACGCAACAAGCCATGAGAGAAGCAGATAACAAAGAAACAGATTTGTTCGTTGAGGATTTTTCTAGTTA
TAGCAATGAGAGAAAAAAGGCTTTAGGTGTTGAAGCTCAATCTTAA

Structures

Toxin

• AlphaFold DB: M3LAD1

Antitoxin

• AlphaFold DB: M3LI72