Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2115300..2115920 Replicon chromosome
Accession NZ_CP122401
Organism Enterobacter roggenkampii strain EOBSR_19

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag QCD67_RS10515 Protein ID WP_008499287.1
Coordinates 2115702..2115920 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag QCD67_RS10510 Protein ID WP_008499288.1
Coordinates 2115300..2115674 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCD67_RS10500 (QCD67_10500) 2110428..2111621 + 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QCD67_RS10505 (QCD67_10505) 2111644..2114790 + 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit AcrB -
QCD67_RS10510 (QCD67_10510) 2115300..2115674 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
QCD67_RS10515 (QCD67_10515) 2115702..2115920 + 219 WP_008499287.1 HHA domain-containing protein Toxin
QCD67_RS10520 (QCD67_10520) 2116127..2116678 + 552 WP_206805139.1 maltose O-acetyltransferase -
QCD67_RS10525 (QCD67_10525) 2116796..2117263 + 468 WP_008499285.1 YlaC family protein -
QCD67_RS10530 (QCD67_10530) 2117235..2118695 - 1461 WP_234099619.1 PLP-dependent aminotransferase family protein -
QCD67_RS10535 (QCD67_10535) 2118797..2119507 + 711 WP_023343500.1 GNAT family protein -
QCD67_RS10540 (QCD67_10540) 2119504..2119644 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
QCD67_RS10545 (QCD67_10545) 2119647..2119907 - 261 WP_006176933.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T276836 WP_008499287.1 NZ_CP122401:2115702-2115920 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT276836 WP_008499288.1 NZ_CP122401:2115300-2115674 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References