Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 267071..267707 Replicon chromosome
Accession NZ_CP122397
Organism Rossellomorea sp. DA94

Toxin (Protein)


Gene name mazF Uniprot ID A0A366ENG2
Locus tag P8596_RS01475 Protein ID WP_034763063.1
Coordinates 267357..267707 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0V8H6B8
Locus tag P8596_RS01470 Protein ID WP_032085355.1
Coordinates 267071..267352 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8596_RS01450 (P8596_01450) 263206..263790 - 585 WP_279725591.1 rhomboid family intramembrane serine protease -
P8596_RS01455 (P8596_01455) 263926..264276 + 351 WP_279725593.1 holo-ACP synthase -
P8596_RS01460 (P8596_01460) 264488..265501 + 1014 WP_279725594.1 outer membrane lipoprotein carrier protein LolA -
P8596_RS01465 (P8596_01465) 265739..266944 + 1206 WP_279725596.1 alanine racemase -
P8596_RS01470 (P8596_01470) 267071..267352 + 282 WP_032085355.1 YlcI/YnfO family protein Antitoxin
P8596_RS01475 (P8596_01475) 267357..267707 + 351 WP_034763063.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
P8596_RS01480 (P8596_01480) 268113..268943 + 831 WP_224521611.1 RsbT co-antagonist protein RsbRA -
P8596_RS01485 (P8596_01485) 268940..269296 + 357 WP_034763058.1 STAS domain-containing protein -
P8596_RS01490 (P8596_01490) 269299..269700 + 402 WP_034763056.1 anti-sigma regulatory factor -
P8596_RS01495 (P8596_01495) 269711..270721 + 1011 WP_224521610.1 PP2C family protein-serine/threonine phosphatase -
P8596_RS01500 (P8596_01500) 270796..271128 + 333 WP_224521609.1 anti-sigma factor antagonist -
P8596_RS01505 (P8596_01505) 271128..271595 + 468 WP_034763252.1 anti-sigma B factor RsbW -
P8596_RS01510 (P8596_01510) 271573..272370 + 798 WP_224521608.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13005.05 Da        Isoelectric Point: 5.1554

>T276831 WP_034763063.1 NZ_CP122397:267357-267707 [Rossellomorea sp. DA94]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTIIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDDALQISVGLIQF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10780.23 Da        Isoelectric Point: 5.9021

>AT276831 WP_032085355.1 NZ_CP122397:267071-267352 [Rossellomorea sp. DA94]
VSESSATTEILIRLPQQLVTELDGFADQENVNRNEFIYRATKMYLRERKKRQLRESMRRGYMEMAKINLAIASEAIQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366ENG2

Antitoxin

Source ID Structure
AlphaFold DB A0A0V8H6B8

References