Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 43182..43918 Replicon plasmid pKP9650-2
Accession NZ_CP122391
Organism Klebsiella pneumoniae strain KP9650

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag QCB43_RS28105 Protein ID WP_004187044.1
Coordinates 43182..43664 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag QCB43_RS28110 Protein ID WP_003026799.1
Coordinates 43652..43918 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCB43_RS28080 (QCB43_28080) 39713..40649 - 937 Protein_40 ISNCY family transposase -
QCB43_RS28085 (QCB43_28085) 40759..40908 + 150 Protein_41 transposase -
QCB43_RS28090 (QCB43_28090) 40924..41034 + 111 Protein_42 IS3 family transposase -
QCB43_RS28095 (QCB43_28095) 41182..41580 - 399 WP_032422684.1 helix-turn-helix domain-containing protein -
QCB43_RS28100 (QCB43_28100) 41629..42975 - 1347 WP_077254728.1 ISNCY family transposase -
QCB43_RS28105 (QCB43_28105) 43182..43664 - 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
QCB43_RS28110 (QCB43_28110) 43652..43918 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
QCB43_RS28115 (QCB43_28115) 45030..45839 - 810 WP_023329017.1 N-formylglutamate deformylase -
QCB43_RS28120 (QCB43_28120) 45832..47040 - 1209 WP_032448288.1 imidazolonepropionase -
QCB43_RS28125 (QCB43_28125) 47052..48446 - 1395 WP_032439652.1 cytosine permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / qnrB4 / blaDHA-15 / mph(A) / floR / aph(6)-Id / aph(3'')-Ib / sul2 / tet(A) iucA / iucB / iucC / iucD / iutA 1..273266 273266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T276829 WP_004187044.1 NZ_CP122391:c43664-43182 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT276829 WP_003026799.1 NZ_CP122391:c43918-43652 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References