Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 150298..151921 Replicon plasmid pKP9650-1
Accession NZ_CP122390
Organism Klebsiella pneumoniae strain KP9650

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag QCB43_RS27185 Protein ID WP_000088046.1
Coordinates 150298..151623 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag QCB43_RS27190 Protein ID WP_024136327.1
Coordinates 151628..151921 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCB43_RS27145 (QCB43_27145) 145319..145675 + 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -
QCB43_RS27150 (QCB43_27150) 146017..146220 - 204 WP_001194555.1 hypothetical protein -
QCB43_RS27155 (QCB43_27155) 146282..147139 - 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
QCB43_RS27160 (QCB43_27160) 147155..147463 - 309 WP_001224687.1 hypothetical protein -
QCB43_RS27165 (QCB43_27165) 148012..148437 - 426 WP_001043843.1 hypothetical protein -
QCB43_RS27170 (QCB43_27170) 148691..149506 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
QCB43_RS27175 (QCB43_27175) 149519..149929 - 411 WP_000985911.1 hypothetical protein -
QCB43_RS27180 (QCB43_27180) 150031..150237 - 207 WP_000134171.1 hypothetical protein -
QCB43_RS27185 (QCB43_27185) 150298..151623 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
QCB43_RS27190 (QCB43_27190) 151628..151921 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
QCB43_RS27195 (QCB43_27195) 152525..152917 - 393 WP_000341066.1 hypothetical protein -
QCB43_RS27200 (QCB43_27200) 153290..153631 + 342 WP_001151575.1 hypothetical protein -
QCB43_RS27205 (QCB43_27205) 153723..153914 + 192 WP_000398480.1 hypothetical protein -
QCB43_RS27210 (QCB43_27210) 153964..154245 + 282 WP_000077926.1 hypothetical protein -
QCB43_RS27215 (QCB43_27215) 154586..154717 - 132 WP_000374059.1 hypothetical protein -
QCB43_RS27220 (QCB43_27220) 154808..156049 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / tet(A) / sul3 / lnu(F) / ant(3'')-Ia / aac(3)-IId / blaTEM-1B / blaLAP-2 / blaCTX-M-55 / qnrS1 / mph(A) / ARR-3 / dfrA14 / aph(3')-Ia - 1..299152 299152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T276828 WP_000088046.1 NZ_CP122390:c151623-150298 [Klebsiella pneumoniae]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT276828 WP_024136327.1 NZ_CP122390:c151921-151628 [Klebsiella pneumoniae]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References